Deep Learning-based Automated Aortic Area and Distensibility Assessment: The Multi-Ethnic Study of Atherosclerosis (MESA)

TL;DR

This study develops and validates a CNN-based method for automatic segmentation and measurement of aortic properties from MRI images, demonstrating high accuracy across diverse populations and external TAA patients.

Contribution

Introduces a U-Net based deep learning model for automated aortic segmentation and distensibility assessment validated on large multi-ethnic and external TAA cohorts.

Findings

High segmentation accuracy with dice coefficients over 97%.

Strong correlation with manual measurements (CCC > 0.95).

Effective generalization to external TAA patient data.

Abstract

This study applies convolutional neural network (CNN)-based automatic segmentation and distensibility measurement of the ascending and descending aorta from 2D phase-contrast cine magnetic resonance imaging (PC-cine MRI) within the large MESA cohort with subsequent assessment on an external cohort of thoracic aortic aneurysm (TAA) patients. 2D PC-cine MRI images of the ascending and descending aorta at the pulmonary artery bifurcation from the MESA study were included. Train, validation, and internal test sets consisted of 1123 studies (24282 images), 374 studies (8067 images), and 375 studies (8069 images), respectively. An external test set of TAAs consisted of 37 studies (3224 images). A U-Net based CNN was constructed, and performance was evaluated utilizing dice coefficient (for segmentation) and concordance correlation coefficients (CCC) of aortic geometric parameters by comparing to manual segmentation and parameter estimation. Dice coefficients for aorta segmentation were 97.6% (CI: 97.5%-97.6%) and 93.6% (84.6%-96.7%) on the internal and external test of TAAs, respectively. CCC for comparison of manual and CNN maximum and minimum ascending aortic areas were 0.97 and 0.95, respectively, on the internal test set and 0.997 and 0.995, respectively, for the external test. CCCs for maximum and minimum descending aortic areas were 0.96 and 0. 98, respectively, on the internal test set and 0.93 and 0.93, respectively, on the external test set. We successfully developed and validated a U-Net based ascending and descending aortic segmentation and distensibility quantification model in a large multi-ethnic database and in an external cohort of TAA patients.