Distributional data analysis via quantile functions and its application to modelling digital biomarkers of gait in Alzheimer's Disease

TL;DR

This paper introduces novel methods using quantile functions and L-moments to analyze distributional wearable data, improving prediction of cognitive function in Alzheimer's disease over traditional summaries.

Contribution

It proposes two new approaches, SOQFR and SOQFR-L, for modeling distributional data with applications to digital biomarkers in Alzheimer's disease.

Findings

Higher predictive performance than traditional summaries.

Stronger associations with clinical cognitive scales.

Effective handling of multi-modal distributional data.

Abstract

With the advent of continuous health monitoring with wearable devices, users now generate their unique streams of continuous data such as minute-level step counts or heartbeats. Summarizing these streams via scalar summaries often ignores the distributional nature of wearable data and almost unavoidably leads to the loss of critical information. We propose to capture the distributional nature of wearable data via user-specific quantile functions (QF) and use these QFs as predictors in scalar-on-quantile-function-regression (SOQFR). As an alternative approach, we also propose to represent QFs via user-specific L-moments, robust rank-based analogs of traditional moments, and use L-moments as predictors in SOQFR (SOQFR-L). These two approaches provide two mutually consistent interpretations: in terms of quantile levels by SOQFR and in terms of L-moments by SOQFR-L. We also demonstrate how to deal with multi-modal distributional data via Joint and Individual Variation Explained (JIVE) using L-moments. The proposed methods are illustrated in a study of association of digital gait biomarkers with cognitive function in Alzheimer's disease (AD). Our analysis shows that the proposed methods demonstrate higher predictive performance and attain much stronger associations with clinical cognitive scales compared to simple distributional summaries.