Moving the epidemic tipping point through topologically targeted social distancing

TL;DR

This paper explores how targeted social distancing strategies, based on network eigenvalues, can effectively prevent epidemics by reducing the largest eigenvalue of social contact networks.

Contribution

It introduces a Markov chain Monte Carlo method to identify link removals that effectively lower the epidemic threshold in social networks.

Findings

Targeted link removal can be more efficient than random removal.

Networks in the well-controlling ensemble are more homogeneous.

80% targeted link removal matches 90% random removal effectiveness.

Abstract

The epidemic threshold of a social system is the ratio of infection and recovery rate above which a disease spreading in it becomes an epidemic. In the absence of pharmaceutical interventions (i.e. vaccines), the only way to control a given disease is to move this threshold by non-pharmaceutical interventions like social distancing, past the epidemic threshold corresponding to the disease, thereby tipping the system from epidemic into a non-epidemic regime. Modeling the disease as a spreading process on a social graph, social distancing can be modeled by removing some of the graphs links. It has been conjectured that the largest eigenvalue of the adjacency matrix of the resulting graph corresponds to the systems epidemic threshold. Here we use a Markov chain Monte Carlo (MCMC) method to study those link removals that do well at reducing the largest eigenvalue of the adjacency matrix. The MCMC method generates samples from the relative canonical network ensemble with a defined expectation value of $\lambda_{max}$. We call this the "well-controlling network ensemble" (WCNE) and compare its structure to randomly thinned networks with the same link density. We observe that networks in the WCNE tend to be more homogeneous in the degree distribution and use this insight to define two ad-hoc removal strategies, which also substantially reduce the largest eigenvalue. A targeted removal of 80\% of links can be as effective as a random removal of 90\%, leaving individuals with twice as many contacts.