Application of Quantitative Systems Pharmacology to guide the optimal dosing of COVID-19 vaccines

TL;DR

This paper proposes using quantitative systems pharmacology (QSP) to guide real-time COVID-19 vaccine dosing adjustments during the pandemic, enabling rational decision-making before full efficacy data are available.

Contribution

It introduces a novel application of QSP modeling for real-time guidance in COVID-19 vaccine dose optimization during ongoing development.

Findings

QSP can inform dose adjustments in real-time

Supports rapid decision-making in vaccine deployment

Enhances understanding of dose-response relationships

Abstract

Optimal use and distribution of Covid-19 vaccines involves adjustments of dosing. Due to the rapidly-evolving pandemic, such adjustments often need to be introduced before full efficacy data are available. As demonstrated in other areas of drug development, quantitative systems pharmacology (QSP) is well placed to guide such extrapolation in a rational and timely manner. Here we propose for the first time how QSP can be applied real time in the context of COVID-19 vaccine development.