Novel Techniques to Assess Predictive Systems and Reduce Their Alarm Burden

TL;DR

This paper introduces utility-based performance metrics for predictive systems, especially in clinical settings, addressing limitations of traditional metrics by accounting for workflow context and temporal relationships.

Contribution

It presents a novel utility metric framework (u-metrics) that better reflects real-world predictor utility and introduces a formal snoozing approach to improve alarm systems.

Findings

u-metrics outperform traditional metrics in clinical prediction scenarios

Snoozing reduces false positives while maintaining event detection

Utility metrics accurately predict performance improvements from snoozing

Abstract

Machine prediction algorithms (e.g., binary classifiers) often are adopted on the basis of claimed performance using classic metrics such as sensitivity and predictive value. However, classifier performance depends heavily upon the context (workflow) in which the classifier operates. Classic metrics do not reflect the realized utility of a predictor unless certain implicit assumptions are met, and these assumptions cannot be met in many common clinical scenarios. This often results in suboptimal implementations and in disappointment when expected outcomes are not achieved. One common failure mode for classic metrics arises when multiple predictions can be made for the same event, particularly when redundant true positive predictions produce little additional value. This describes many clinical alerting systems. We explain why classic metrics cannot correctly represent predictor performance in such contexts, and introduce an improved performance assessment technique using utility functions to score predictions based on their utility in a specific workflow context. The resulting utility metrics (u-metrics) explicitly account for the effects of temporal relationships on prediction utility. Compared to traditional measures, u-metrics more accurately reflect the real world costs and benefits of a predictor operating in a live clinical context. The improvement can be significant. We also describe a formal approach to snoozing, a mitigation strategy in which some predictions are suppressed to improve predictor performance by reducing false positives while retaining event capture. Snoozing is especially useful for predictors that generate interruptive alarms. U-metrics correctly measure and predict the performance benefits of snoozing, whereas traditional metrics do not.