DNA Nucleobase Interaction Driven Electronic and Optical Fingerprints in Gallium Selenide Monolayer for DNA Sequencing Devices

TL;DR

This study explores how GaSe monolayers interact with DNA nucleobases, revealing their potential for reusable, highly sensitive DNA sequencing devices through electronic and optical fingerprinting.

Contribution

The paper demonstrates the use of GaSe monolayers for DNA sequencing, showing their reusability and optical/electronic sensing capabilities based on nucleobase interactions.

Findings

Nucleobases are physisorbed on GaSe with specific binding energies.

GaSe exhibits anisotropic optical response beneficial for polarized sensors.

Quantum capacitance is identified as a key sensing parameter.

Abstract

The interaction of DNA nucleobases with monolayer GaSe has been studied with in DFT framework using vdW functional. We found that nucleobases are physisorbed on the GaSe monolayer. The order of binding energy per atom is C > T > G > A. The room temperature recovery time estimated to be maximum of 113.88 micro sec. for T+GaSe indicting reusability of the GaSe based devices. The modulation in the electronic structures of GaSe has been clearly captured within the simulated STM measurements. We also demonstrate quantum capacitance as a key parameter for sensing applications. Furthermore, in optical properties, electron energy loss (EEL) spectra show red shift in photon energy on nucleobase adsorption in UV region. In nutshell, GaSe monolayer exhibit anisotropic optical response in UV-region which can be highly beneficial for developing polarized optical sensors. Our results demonstrate that GaSe monolayer can be utilized to fabricate reusable DNA sequencing devices for biotechnology and medical science.