Peptipedia: a comprehensive database for peptide research supported by Assembled predictive models and Data Mining approaches

TL;DR

Peptipedia is a comprehensive, user-friendly database integrating data from 30 peptide sources, supporting research and biotechnological applications with various analysis tools and open access availability.

Contribution

It introduces the largest peptide database with integrated predictive models and data mining tools, enhancing usability for drug design and bioengineering.

Findings

Largest repository of peptide data with 30 sources

Enhanced usability with multiple analysis services

Open-access platform for research and development

Abstract

Motivation: Peptides have attracted the attention in this century due to their remarkable therapeutic properties. Computational tools are being developed to take advantage of existing information, encapsulating knowledge and making it available in a simple way for general public use. However, these are property-specific redundant data systems, and usually do not display the data in a clear way. In some cases, information download is not even possible. This data needs to be available in a simple form for drug design and other biotechnological applications. Results: We developed Peptipedia, a user-friendly database and web application to search, characterise and analyse peptide sequences. Our tool integrates the information from thirty previously reported databases, making it the largest repository of peptides with recorded activities so far. Besides, we implemented a variety of services to increase our tool's usability. The significant differences of our tools with other existing alternatives becomes a substantial contribution to develop biotechnological and bioengineering applications for peptides. Availability: Peptipedia is available for non-commercial use as an open-access software, licensed under the GNU General Public License, version GPL 3.0. The web platform is publicly available at pesb2.cl/peptipedia. Both the source code and sample datasets are available in the GitHub repository https://github.com/CristoferQ/PeptideDatabase. Contact: david.medina@cebib.cl, ana.sanchez@ing.uchile.cl