The AL-Gaussian Distribution as the Descriptive Model for the Internal Proactive Inhibition in the Standard Stop Signal Task
Mohsen Soltanifar, Michael Escobar, Annie Dupuis, Andre Chevrier and, Russell Schachar

TL;DR
This paper introduces the AL-Gaussian distribution as a new model to accurately describe proactive inhibition in the stop signal task, filling a gap in existing methods for estimating its distribution.
Contribution
The paper proposes the AL-Gaussian distribution as a novel parametric model for proactive inhibition, based on assumptions of independent trial reaction times and Ex-Gaussian models.
Findings
The AL-Gaussian model uniquely describes proactive inhibition distribution.
Its hazard function is monotonically increasing.
It captures key shape features of proactive inhibition.
Abstract
Measurements of response inhibition components of reactive inhibition and proactive inhibition within the stop signal paradigm have been of special interest for researchers since the 1980s. While frequentist nonparametric and Bayesian parametric methods have been proposed to precisely estimate the entire distribution of reactive inhibition, quantified by stop signal reaction times(SSRT), there is no method yet in the stop-signal task literature to precisely estimate the entire distribution of proactive inhibition. We introduce an Asymmetric Laplace Gaussian (ALG) model to describe the distribution of proactive inhibition. The proposed method is based on two assumptions of independent trial type(go/stop) reaction times, and Ex-Gaussian (ExG) models for them. Results indicated that the four parametric, ALG model uniquely describes the proactive inhibition distribution and its key shape…
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Taxonomy
TopicsComputational Drug Discovery Methods · Receptor Mechanisms and Signaling · Neural dynamics and brain function
