Magnetic Particles for Multidimensional In-vitro Bioanalysis

TL;DR

This paper reviews the role of magnetic particles in enhancing multidimensional bioanalysis, emphasizing recent technological advances, applications, and future challenges in the field.

Contribution

It provides a comprehensive overview of magnetic particle properties and their integration with sensor technologies for improved multiplex bioanalysis.

Findings

Magnetic particles enable high-throughput multiplex bioanalysis.

Recent sensor integration improves detection sensitivity.

Challenges include biocompatibility and scalability.

Abstract

Multidimensional or multiplex bioanalysis represents a crucial approach to improve diagnostic precision, increase assay throughput and advance fundamental discoveries in analytical industry, life science and nanomedicine. Along this line, bio-interfacing magnetic particles have been playing an important role. Fully exploiting the properties of magnetic particles is the key to tailoring recent technology development for better translational outcomes. In this mini-review, typical magnetophysical dimensions of magnetic particles are introduced. Recent progress of implementing these dimensions with advanced sensor and actuator technologies in multiplex bioanalysis is discussed. Outlooks on potential biomedical applications and challenges are provided.