In-vitro and Particle Image Velocimetry Studies of Dry Powder Inhalers

TL;DR

This study uses in-vitro and particle image velocimetry techniques to analyze flow dynamics in dry powder inhalers, showing that device modifications like adding a grid improve aerosol delivery efficiency by reducing throat deposition.

Contribution

It demonstrates how PIV measurements can enhance in-vitro assessments and guide design improvements for more efficient DPI devices.

Findings

All device models achieved FPF > 50% indicating good lung deposition.

Presence of a grid reduces lateral flow spreading and throat deposition.

Flow visualization reveals swirling jets contribute to particle loss in some designs.

Abstract

Inhalation drug delivery has seen a swift rise in the use of dry powder inhalers (DPIs) to treat chronic respiratory conditions. However, universal adoption of DPIs has been restrained due to their low efficiencies and significant drug losses in the mouth-throat region. Aerosol efficiency of DPIs is closely related to the fluid-dynamics characteristics of the inhalation flow generated from the devices, which in turn are influenced by the device design. In-vitro and particle image velocimetry (PIV) have been used in this study to assess the aerosol performance of a model carrier formulation delivered by DPI devices and to investigate their flow characteristics. Four DPI device models, with modification to their tangential inlets and addition of a grid, have been explored. Similar aerosol performances were observed for all four device models, with FPF larger than 50%, indicating desirable lung deposition. A high swirling and recirculating jet-flow emerging from the mouthpiece of the DPI models without the grid was observed, which contributed to particle deposition in the throat. DPI models where the grid was present showed a straightened outflow without undesired lateral spreading, that reduced particle deposition in the throat and mass retention in the device. These findings demonstrate that PIV measurements strengthen in-vitro evaluation and can be jointly used to develop high-performance DPIs.