Stability bounds of a delay visco-elastic rheological model with substrate friction

TL;DR

This paper introduces a rheological model combining elastic, viscous, and frictional elements to analyze oscillatory cell behaviors, deriving stability bounds and exploring how delay, remodelling, and substrate friction influence stability and oscillations.

Contribution

It presents a novel delay visco-elastic rheological model with substrate friction and analytically derives stability bounds, extending to non-linear strains for sustained oscillations.

Findings

Increasing delay and remodelling rate destabilize the model.

Higher substrate friction destabilizes oscillations.

Non-linear extension can produce sustained oscillations.

Abstract

Cells and tissues exhibit oscillatory deformations during remodelling, migration or embryogenesis. Although it has been shown that these oscillations correlate with cell biochemical signalling, it is yet unclear the role of these oscillations in triggering drastic cell reorganisation events or instabilities, and the coupling of this oscillatory response with tested visco-elastic properties. We here present a rheological model that incorporates elastic, viscous and frictional components, and that is able to generate oscillatory response through a delay adaptive process of the rest-length. We analyse its stability properties as a function of the model parameters and deduce analytical bounds of the stable domain. While increasing values of the delay and remodelling rate render the model unstable, we also show that increasing friction with the substrate destabilise the oscillatory response. Furthermore, we numerically verify that the extension of the model to non-linear strain measures is able to generate sustained oscillations that alternate between stable and unstable regions.