Multiple Idiopathic Cervical Root Resorption: A Challenge for a Transdisciplinary Medical-Dental Team

TL;DR

This paper discusses the complex and often elusive causes of multiple idiopathic cervical root resorption (MICRR), emphasizing the importance of interdisciplinary collaboration for early diagnosis and improved management.

Contribution

It highlights the need for transdisciplinary research and integrated clinical strategies to understand and treat MICRR effectively.

Findings

MICRR is an aggressive, idiopathic form of external root resorption near the CEJ.

Multiple potential etiologies include systemic conditions, genetic factors, and environmental influences.

Collaborative approaches are essential for early detection and management.

Abstract

While tooth root resorption is a normal physiological process required for resorption and exfoliation of primary teeth, root resorption of adult teeth is largely pathological. This perspective focuses on multiple idiopathic cervical root resorption (MICRR), an aggressive form of external root resorption that occurs near the cemento-enamel junction (CEJ). The cause of MICRR remains elusive, however, it is mediated primarily by osteoclasts/odontoclasts. Accumulating case studies and experiments in animal models have provided insights into defining the etiologies and pathophysiological mechanisms for MICRR, which include: systemic conditions and syndromes, inherited genetic variants affecting osteoclast/odontoclast activity, altered periodontal structures, drug-induced root resorption and rebound effects after cessation of anti-resorptive treatment, chemotherapy, exposure to pets or viral infections, and other factors such as inflammatory conditions or trauma. To determine the causative factors, at minimum, a comprehensive health history should be collected for all patients by dental care providers, discussed with other health care providers and appropriate collaborations established. The examples highlighted in this perspective emphasize the need for transdisciplinary research collaborations coupled with integrated management strategies between medicine and dentistry in order to identify cause(s) early and improve clinical outcomes.