A statistical method for estimating the no-observed-adverse-event-level
Ludwig A. Hothorn
TL;DR
This paper introduces a simple statistical test for estimating the NOAEL in toxicology, highlighting its advantages and limitations, and demonstrates its use across various bioassay datasets.
Contribution
It proposes a straightforward method for NOAEL estimation, complementing the recommended BMD approach in toxicological risk assessment.
Findings
The method is applicable to diverse toxicity bioassays.
It offers a practical alternative to complex BMD calculations.
The paper discusses the method's advantages and limitations.
Abstract
In toxicological risk assessment the benchmark dose (BMD) is recommended instead of the no-observed-adverse effect-level (NOAEL). Still a simple test procedure to estimate NOAEL is proposed here, explaining its advantages and disadvantages. Versatile applicability is illustrated using four different data examples of selected in vivo toxicity bioassays.
Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsStatistical Methods in Clinical Trials · Carcinogens and Genotoxicity Assessment · Effects and risks of endocrine disrupting chemicals