Automatic Segmentation and Location Learning of Neonatal Cerebral Ventricles in 3D Ultrasound Data Combining CNN and CPPN

TL;DR

This study develops and evaluates CNN-based algorithms, enhanced with CPPN, for automatic segmentation of neonatal cerebral ventricles in 3D ultrasound data, achieving accuracy comparable to intraobserver variability.

Contribution

It introduces the use of CPPN to encode CVS location in CNNs, improving segmentation accuracy with fewer layers in neonatal 3D ultrasound analysis.

Findings

CPPN enhances CNNs by encoding CVS location.

3D CNNs outperform 2D CNNs in normal ventricles.

Segmentation accuracy reaches intraobserver variability levels.

Abstract

Preterm neonates are highly likely to suffer from ventriculomegaly, a dilation of the Cerebral Ventricular System (CVS). This condition can develop into life-threatening hydrocephalus and is correlated with future neuro-developmental impairments. Consequently, it must be detected and monitored by physicians. In clinical routing, manual 2D measurements are performed on 2D ultrasound (US) images to estimate the CVS volume but this practice is imprecise due to the unavailability of 3D information. A way to tackle this problem would be to develop automatic CVS segmentation algorithms for 3D US data. In this paper, we investigate the potential of 2D and 3D Convolutional Neural Networks (CNN) to solve this complex task and propose to use Compositional Pattern Producing Network (CPPN) to enable the CNNs to learn CVS location. Our database was composed of 25 3D US volumes collected on 21 preterm nenonates at the age of $35.8 \pm 1.6$ gestational weeks. We found that the CPPN enables to encode CVS location, which increases the accuracy of the CNNs when they have few layers. Accuracy of the 2D and 3D CNNs reached intraobserver variability (IOV) in the case of dilated ventricles with Dice of $0.893 \pm 0.008$ and $0.886 \pm 0.004$ respectively (IOV = $0.898 \pm 0.008$) and with volume errors of $0.45 \pm 0.42$ cm$^3$ and $0.36 \pm 0.24$ cm$^3$ respectively (IOV = $0.41 \pm 0.05$ cm$^3$). 3D CNNs were more accurate than 2D CNNs in the case of normal ventricles with Dice of $0.797 \pm 0.041$ against $0.776 \pm 0.038$ (IOV = $0.816 \pm 0.009$) and volume errors of $0.35 \pm 0.29$ cm$^3$ against $0.35 \pm 0.24$ cm$^3$ (IOV = $0.2 \pm 0.11$ cm$^3$). The best segmentation time of volumes of size $320 \times 320 \times 320$ was obtained by a 2D CNN in $3.5 \pm 0.2$ s.