Regional compartmentalization in multienzyme-related biomaterials system

TL;DR

This paper explores how spatially organized multienzyme compartments can enhance catalytic efficiency and synergy in biochemical systems, with implications for biomaterials and biotechnological applications.

Contribution

It analyzes the feasibility and benefits of regional compartments in multienzyme systems for improving biochemical reaction performance.

Findings

Regional compartments can enhance enzyme synergy.

Ordered organization improves catalytic efficiency.

Potential applications in biomaterials and biotechnologies.

Abstract

Multienzyme cascaded reactions are widely utilized because they can generate value-added biomaterials and biodevices from simple raw materials. However, how to promote the catalytic efficiency and synergistic effect of the multienzyme system is proved to be a challengeable point. Recent discovery repeatedly emphasized the strategy of assembled multienzyme complexes or forming subcellular compartments for spacial optimization. This highly ordered and tunable organization contributes to various biochemical processes. This dissertation focuses mainly on analysis and progresses in this cascaded strategy, regarding the feasibility of regional compartments for natural or artificial biochemical reactions in vivo and vitro, simultaneously.