An Investigation of Commercial Iron Oxide Nanoparticles: Advanced Structural and Magnetic Properties Characterization

TL;DR

This paper thoroughly characterizes commercial iron oxide magnetic nanoparticles using various techniques, providing insights into their structural and magnetic properties for biomedical applications.

Contribution

It offers a comprehensive analysis of Ocean NanoTech's iron oxide nanoparticles, including standardized procedures for assessing their magnetic responses in different conditions.

Findings

Detailed magnetic and structural profiles of the nanoparticles

Standardized methods for dynamic magnetic response measurement

Guidelines for selecting nanoparticles for specific biomedical uses

Abstract

Magnetic nanoparticles (MNPs) have been extensively used as tiny heating sources in magnetic hyperthermia therapy, contrast agents in magnetic resonance imaging (MRI), tracers in magnetic particle imaging (MPI), carriers for drug/gene delivery, etc. There have emerged many magnetic nanoparticle/microbeads suppliers since the last decade, such as Ocean NanoTech, Nanoprobes, US Research Nanomaterials, Miltenyi Biotec, micromod Partikeltechnologie GmbH, and nanoComposix, etc. In this paper, we report the physical and magnetic characterizations on iron oxide nanoparticle products from Ocean NanoTech. Standard characterization tools such as Vibrating-Sample Magnetometer (VSM), X-Ray Diffraction (XRD), Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM), and Zeta Potential Analyzer are used to provide magnetic nanoparticle customers and researchers with an overview of these iron oxide nanoparticle products. In addition, the dynamic magnetic responses of these iron oxide nanoparticles in aqueous solutions are investigated under low and high frequency alternating magnetic fields, giving a standardized operating procedure for characterizing the MNPs from Ocean NanoTech, thereby yielding the best of magnetic nanoparticles for different applications.