Local power estimation of neuromodulations using point process modeling

TL;DR

This paper introduces a novel method called MPP spectrogram for high-resolution local power estimation in brain signals, surpassing traditional spectral analysis limitations by modeling neuromodulations as a point process.

Contribution

The paper presents a new point process-based approach for precise local power estimation in neural signals, improving temporal resolution over traditional spectral methods.

Findings

MPP spectrogram correlates strongly with spectral power density.

Method effectively tracks local power variations in neural data.

Applicable to both animal and human brain recordings.

Abstract

Extracellular electrical potentials (EEP) recorded from the brain are an active manifestation of all cellular processes that propagate within a volume of brain tissue. A standard approach for their quantification are power spectral analyses methods that reflect the global distribution of signal power over frequency. However, these methods incorporate analysis windows to achieve locality and therefore, are limited by the inherent trade - off between time and frequency resolutions. In this paper, we present a novel approach to estimate local power more precisely at a resolution as high as the sampling frequency. Our methods are well grounded on established neurophysiology of the bio-signals where we model EEPs as comprising of two components: neuromodulations and background activity. A local measure of power, we call Marked Point Process (MPP) spectrogram, is then derived as a power - weighted intensity function of the point process for neuromodulations. We demonstrate our results on two datasets: 1) local field potentials recorded from the prefrontal cortex of 3 rats performing a working memory task and 2) EEPs recorded via electroencephalography from the visual cortex of human subjects performing a conditioned stimulus task. A detailed analysis of the power - specific marked features of neuromodulations confirm high correlation between power spectral density and power in neuromodulations establishing the aptness of MPP spectrogram as a finer measure of power where it is able to track local variations in power while preserving the global structure of signal power distribution.