Quantitative reintepretation of quartz-crystal-microbalance experiments with adsorbed particles using analytical hydrodynamics

TL;DR

This paper develops an analytical hydrodynamic model for quartz crystal microbalance (QCM) experiments with adsorbed particles, providing a firm theoretical basis and validating it against experiments and simulations, enhancing QCM's predictive power.

Contribution

It introduces a hydrodynamic theory for QCM with discrete particles, replacing ad-hoc models and fitting parameters, and validates it across diverse experimental data.

Findings

Analytical expressions match experimental and simulation data.

Hydrodynamic impedance dominates QCM response.

Physico-chemical forces require hydrodynamic reinterpretation.

Abstract

Despite being a fundamental tool in soft matter research, quartz crystal microbalance (QCM) analyses of discrete macromolecules in liquid so far lack a firm theoretical basis. Currently, acoustic signals are qualitatively interpreted using ad-hoc frameworks based on effective electrical circuits, effective springs and trapped-solvent models with abundant fitting parameters. Nevertheless, due to its extreme sensitivity, the QCM technique pledges to become an accurate predictive tool. Using unsteady low Reynolds hydrodynamics we derive analytical expressions for the acoustic impedance of adsorbed discrete spheres. Our theory is successfully validated against 3D simulations and a plethora of experimental results covering more than a decade of research on proteins, viruses, liposomes, massive nanoparticles, with sizes ranging from few to hundreds of nanometers. The excellent agreement without fitting constants clearly indicates that the acoustic response is dominated by the hydrodynamic impedance, thus, deciphering the secondary contribution of physico-chemical forces will first require a hydrodynamic-reinterpretation of QCM.