Measuring breathing induced oesophageal motion and its dosimetric impact

TL;DR

This study quantifies oesophageal motion during radiotherapy using advanced algorithms, revealing significant heterogeneity and impact on dose delivery, emphasizing the need for individualized motion assessment in treatment planning.

Contribution

Introduces a voxel-wise motion measurement method and a motion model for the oesophagus, improving accuracy over traditional contouring methods in radiotherapy planning.

Findings

Mean maximal motion amplitudes around 4.55-10.78 mm across axes.

In 50% of cases, dosimetric criteria were violated due to motion.

3DCT contours underestimated organ coverage by 14%.

Abstract

Stereotactic body radiation therapy allows for a precise and accurate dose delivery. Organ motion during treatment bears the risk of undetected high dose healthy tissue exposure. An organ very susceptible to high dose is the oesophagus. Its low contrast on CT and the oblong shape renders motion estimation difficult. We tackle this issue by modern algorithms to measure the oesophageal motion voxel-wise and to estimate motion related dosimetric impact. Oesophageal motion was measured using deformable image registration and 4DCT of 11 internal and 5 public datasets. Current clinical practice of contouring the organ on 3DCT was compared to timely resolved 4DCT contours. The dosimetric impact of the motion was estimated by analysing the trajectory of each voxel in the 4D dose distribution. Finally an organ motion model was built, allowing for easier patient-wise comparisons. Motion analysis showed mean absolute maximal motion amplitudes of 4.55 +/- 1.81 mm left-right, 5.29 +/- 2.67 mm anterior-posterior and 10.78 +/- 5.30 mm superior-inferior. Motion between the cohorts differed significantly. In around 50 % of the cases the dosimetric passing criteria was violated. Contours created on 3DCT did not cover 14 % of the organ for 50 % of the respiratory cycle and the 3D contour is around 38 % smaller than the union of all 4D contours. The motion model revealed that the maximal motion is not limited to the lower part of the organ. Our results showed motion amplitudes higher than most reported values in the literature and that motion is very heterogeneous across patients. Therefore, individual motion information should be considered in contouring and planning.