Marginal Contribution Feature Importance -- an Axiomatic Approach for The Natural Case
Amnon Catav, Boyang Fu, Jason Ernst, Sriram Sankararaman, Ran, Gilad-Bachrach

TL;DR
This paper introduces a unique axiomatic framework for feature importance in natural scenarios, specifically for understanding phenomena like diseases, and proposes the Marginal Contribution Feature Importance (MCI) as the sole function satisfying these axioms.
Contribution
It develops axioms for feature importance in natural scenarios and proves MCI as the unique function meeting these criteria, with analysis and comparison to existing methods.
Findings
MCI uniquely satisfies the proposed axioms.
Theoretical analysis of MCI's properties.
Empirical comparison shows MCI's advantages over other scores.
Abstract
When training a predictive model over medical data, the goal is sometimes to gain insights about a certain disease. In such cases, it is common to use feature importance as a tool to highlight significant factors contributing to that disease. As there are many existing methods for computing feature importance scores, understanding their relative merits is not trivial. Further, the diversity of scenarios in which they are used lead to different expectations from the feature importance scores. While it is common to make the distinction between local scores that focus on individual predictions and global scores that look at the contribution of a feature to the model, another important division distinguishes model scenarios, in which the goal is to understand predictions of a given model from natural scenarios, in which the goal is to understand a phenomenon such as a disease. We develop a…
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Taxonomy
TopicsBioinformatics and Genomic Networks · Explainable Artificial Intelligence (XAI) · Computational Drug Discovery Methods
