Research on mouse brain tissue optical model based on Monte Carlo

TL;DR

This paper models photon transmission in mouse brain tissue with and without the skull using Monte Carlo simulations, providing insights into optical properties relevant for brain imaging.

Contribution

It introduces a Monte Carlo-based optical model of mouse brain tissue considering skull presence, aiding optical imaging research.

Findings

Photon distribution extends farther without skull.

Optical absorption density and fluence rate are more fusiform with skull.

Skull presence affects photon propagation patterns.

Abstract

We studied the transmission of photons in mouse brain in both with and without intact skull states using Monte Carlo method. Photon track, optical absorption density and fluence rate were used as indicators for analysis. We found that, the photon distribution without intact skull goes farther in both longitudinal and transverse directions compared with that of with intact skull. The distribution of optical absorption density and fluence rate was fusiform and rounder on the whole with intact skull. This study will provide reference and theoretical guidance for the optical imaging of mouse brain and the study of the mouse and human brain.