Influence of segmentation accuracy in structural MR head scans on electric field computation for TMS and tES

TL;DR

This study investigates how segmentation accuracy of MRI-derived head models affects electric field calculations in TMS and tES, revealing tissue-dependent sensitivities and quantifying the impact of segmentation errors.

Contribution

It introduces a deep learning-based method to generate head models with varying segmentation quality and assesses their influence on electric field estimations in neurostimulation.

Findings

Segmentation errors in CSF significantly affect electric field estimates.

Gray matter segmentation errors can cause up to 6% increase in electric field.

Tissue-specific sensitivity to segmentation accuracy varies across brain tissues.

Abstract

In several diagnosis and therapy procedures based on electrostimulation effect, the internal physical quantity related to the stimulation is the induced electric field. To estimate the induced electric field in an individual human model, the segmentation of anatomical imaging, such as (magnetic resonance image (MRI) scans, of the corresponding body parts into tissues is required. Then, electrical properties associated with different annotated tissues are assigned to the digital model to generate a volume conductor. An open question is how segmentation accuracy of different tissues would influence the distribution of the induced electric field. In this study, we applied parametric segmentation of different tissues to exploit the segmentation of available MRI to generate different quality of head models using deep learning neural network architecture, named ForkNet. Then, the induced electric field are compared to assess the effect of model segmentation variations. Computational results indicate that the influence of segmentation error is tissue-dependent. In brain, sensitivity to segmentation accuracy is relatively high in cerebrospinal fluid (CSF), moderate in gray matter (GM) and low in white matter for transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES). A CSF segmentation accuracy reduction of 10% in terms of Dice coefficient (DC) lead to decrease up to 4% in normalized induced electric field in both applications. However, a GM segmentation accuracy reduction of 5.6% DC leads to increase of normalized induced electric field up to 6%. Opposite trend of electric field variation was found between CSF and GM for both TMS and tES. The finding obtained here would be useful to quantify potential uncertainty of computational results.