Nonlinear stability of chemotactic clustering with discontinuous advection
Vincent Calvez, Franca Hoffmann

TL;DR
This paper analyzes the nonlinear stability of bacterial chemotactic clustering with a discontinuous advection speed, overcoming mathematical challenges to prove exponential relaxation to equilibrium.
Contribution
It introduces a perturbative approach to handle discontinuous advection and derives an improved Poincaré inequality for stability analysis.
Findings
Exponential relaxation to equilibrium established.
Numerical simulations support theoretical results.
Method handles discontinuities in chemotaxis models.
Abstract
We perform the nonlinear stability analysis of a chemotaxis model of bacterial self-organization, assuming that bacteria respond sharply to chemical signals. The resulting discontinuous advection speed represents the key challenge for the stability analysis. We follow a perturbative approach, where the shape of the cellular profile is clearly separated from its global motion, allowing us to circumvent the discontinuity issue. Further, the homogeneity of the problem leads to two conservation laws, which express themselves in differently weighted functional spaces. This discrepancy between the weights represents another key methodological challenge. We derive an improved Poincar\'e inequality that allows to transfer the information encoded in the conservation laws to the appropriately weighted spaces. As a result, we obtain exponential relaxation to equilibrium with an explicit rate. A…
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Taxonomy
TopicsMathematical Biology Tumor Growth · Medical Image Segmentation Techniques · Cell Image Analysis Techniques
