Label-free, non-contact, in-vivo ophthalmic imaging using photoacoustic remote sensing microscopy

TL;DR

This paper demonstrates the first non-contact, label-free in-vivo imaging of ocular vasculature using photoacoustic remote sensing microscopy, revealing detailed structures of mouse eye tissues and offering potential for ocular disease diagnosis.

Contribution

It introduces a novel non-contact photoacoustic imaging technique for in-vivo ocular tissues, expanding capabilities for ophthalmic diagnostics.

Findings

Clear imaging of iris, sclera, and retina vasculature

First in-vivo non-contact photoacoustic imaging of ocular tissue

Potential to improve ocular disease diagnosis

Abstract

We present the first label-free, non-contact, in-vivo imaging of the ocular vasculature using photoacoustic remote sensing (PARS) microscopy. Both anterior and posterior segments mouse eye were imaged. Vasculature of iris, sclera and retina tissues were clearly resolved. To best of our knowledge this the first study showing non-contact photoacoustic imaging conducted on in-vivo ocular tissue. We believe that PARS microscopy has the potential to advance the diagnosis and treatment of ocular diseases.