TL;DR
MOSGA is a user-friendly, open-source genome annotation framework for eukaryotic genomes that integrates multiple tools, providing an accessible and customizable solution for biologists to annotate genomes efficiently.
Contribution
MOSGA introduces a modular, web-based genome annotation framework with integrated visualization and submission features, simplifying the annotation process for non-experts.
Findings
Provides a fully integrated genome browser.
Enables easy submission to NCBI.
Offers a customizable, extendible Snakemake backend.
Abstract
The generation of high-quality assemblies, even for large eukaryotic genomes, has become a routine task for many biologists thanks to recent advances in sequencing technologies. However, the annotation of these assemblies - a crucial step towards unlocking the biology of the organism of interest - has remained a complex challenge that often requires advanced bioinformatics expertise. Here we present MOSGA, a genome annotation framework for eukaryotic genomes with a user-friendly web-interface that generates and integrates annotations from various tools. The aggregated results can be analyzed with a fully integrated genome browser and are provided in a format ready for submission to NCBI. MOSGA is built on a portable, customizable, and easily extendible Snakemake backend, and thus, can be tailored to a wide range of users and projects. We provide MOSGA as a publicly free available web…
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