Positive Equilibria of Hill-Type Kinetic Systems

TL;DR

This paper introduces a new framework for analyzing positive equilibria in Hill-type kinetic systems by associating them with poly-PL systems, enabling the application of existing robustness results and extending the theory to more general kinetics.

Contribution

It develops a novel approach linking Hill-type kinetics to poly-PL systems, allowing the transfer of known results on concentration robustness and complex balancing.

Findings

Established equivalence of equilibria sets between Hill-type and poly-PL systems.

Extended ACR and BCR theories to Hill-type kinetic systems.

Provided a foundation for analyzing robustness in generalized kinetic models.

Abstract

This work introduces a novel approach to study properties of positive equilibria of a chemical reaction network $\mathscr{N}$ endowed with Hill-type kinetics $K$, called a Hill-type kinetic (HTK) system $\left(\mathscr{N},K\right)$, including their multiplicity and concentration robustness in a species. We associate a unique positive linear combination of power-law kinetic systems called poly-PL kinetic (PYK) system $\left( {\mathscr{N},{K_\text{PY}}} \right)$ to the given HTK system. The associated system has the key property that its equilibria sets coincide with those of the Hill-type system, i.e., ${E_ + }\left( {\mathscr{N},K} \right) = {E_ + }\left( {\mathscr{N},{K_\text{PY}}} \right)$ and ${Z_ + }\left( {\mathscr{N},K} \right) = {Z_ + }\left( {\mathscr{N},{K_\text{PY}}} \right)$. This allows us to identify two novel subsets of the Hill-type kinetics, called PL-equilibrated and PL-complex balanced kinetics, to which recent results on absolute concentration robustness (ACR) of species and complex balancing at positive equilibria of power-law (PL) kinetic systems can be applied. Our main results also include the Shinar-Feinberg ACR Theorem for PL-equilibrated HT-RDK systems (i.e., subset of complex factorizable HTK systems), which establishes a foundation for the analysis of ACR in HTK systems, and the extension of the results of M\"uller and Regensburger on generalized mass action systems to PL-complex balanced HT-RDK systems. In addition, we derive the theory of balanced concentration robustness (BCR) in an analogous manner to ACR for PL-equilibrated systems. Finally, we provide further extensions of our results to a more general class of kinetics, which includes quotients of poly-PL functions.