Modified multiplicative decomposition model for tissue growth: Beyond the initial stress-free state

TL;DR

This paper introduces a modified multiplicative decomposition model for biological tissue growth that incorporates initial residual stress, providing a more realistic framework for predicting tissue stress distribution and morphology.

Contribution

It proposes a novel model where initial residual stress is integrated into tissue growth modeling, extending beyond the traditional stress-free initial state assumption.

Findings

Initial residual stress significantly influences tissue stress distribution.

The model predicts different morphologies based on initial residual stress levels.

The approach improves understanding of tissue growth mechanics.

Abstract

The multiplicative decomposition model is widely employed for predicting residual stresses and morphologies of biological tissues due to growth. However, it relies on the assumption that the tissue is initially in a stress-free state, which conflicts with the observations that any growth state of tissue is under a significant level of residual stresses that helps to maintain its ideal mechanical conditions. Here, we propose a modified multiplicative decomposition model where the initial state (or reference configuration) of biological tissue is endowed with residual stress instead of being stress-free. Releasing theoretically the initial residual stress, the initially stressed state is first transmitted into a virtual stress-free state, resulting in an initial elastic deformation. The initial virtual stress-free state subsequently grows to another counterpart with a growth deformation and the latter is further integrated into its natural configuration with an excessive elastic deformation that ensures tissue compatibility. With this decomposition, the total deformation may be expressed as the product of elastic deformation, growth deformation and initial elastic deformation, while the corresponding free energy density depends on the initial residual stress and the total deformation. We address three key issues: explicit expression of the free energy density,predetermination of the initial elastic deformation, and initial residual stress. Finally, we consider a tubular organ to demonstrate the effects of the proposed initial residual stress on stress distribution and on shape formation through an incremental stability analysis. Our results suggest that the initial residual stress exerts a major influence on the growth stress and the morphology of tissues.