Integrodifference master equation describing actively growing blood vessels in angiogenesis

TL;DR

This paper introduces a new integrodifference master equation model for actively growing blood vessels in angiogenesis, incorporating stochastic particle dynamics, reaction-diffusion fields, and vessel fusion, providing a comprehensive framework for tumor-induced blood vessel formation.

Contribution

It develops a novel discrete master equation for vessel tip density that includes source, sink, and fusion processes, advancing modeling of angiogenesis beyond existing approaches.

Findings

The model captures vessel growth and fusion dynamics.

Results illustrate the applicability to key angiogenesis models.

The approach integrates stochastic, reaction-diffusion, and network formation aspects.

Abstract

We study a system of particles in a two-dimensional geometry that move according to a reinforced random walk with transition probabilities dependent on the solutions of reaction-diffusion equations for the underlying fields. A birth process and a history-dependent killing process are also considered. This system models tumor-induced angiogenesis, the process of formation of blood vessels induced by a growth factor released by a tumor. Particles represent vessel tip cells, whose trajectories constitute the growing vessel network. New vessels appear and may fuse with existing ones during their evolution. Thus, the system is described by tracking the density of active tips, calculated as an ensemble average over many realizations of the stochastic process. Such density satisfies a novel discrete master equation with source and sink terms. The sink term is proportional to a space-dependent and suitably fitted killing coefficient. Results are illustrated studying two influential angiogenesis models.