Inspection of histological 3D reconstructions in virtual reality

TL;DR

This paper introduces a virtual reality visualization tool for inspecting and analyzing 3D histological reconstructions, enhancing quality control and research insights in medical imaging.

Contribution

It presents a novel VR-based visualization approach for 3D histological data, improving inspection, annotation, and analysis capabilities for medical research.

Findings

VR visualization improves inspection efficiency

Enables detailed microanatomical analysis

Facilitates quality control in 3D reconstructions

Abstract

3D reconstruction is a challenging current topic in medical research. We perform 3D reconstructions from serial sections stained by immunohistological methods. This paper presents an immersive visualisation solution to quality control (QC), inspect, and analyse such reconstructions. QC is essential to establish correct digital processing methodologies. Visual analytics, such as annotation placement, mesh painting, and classification utility, facilitates medical research insights. We propose a visualisation in virtual reality (VR) for these purposes. In this manner, we advance the microanatomical research of human bone marrow and spleen. Both 3D reconstructions and original data are available in VR. Data inspection is streamlined by subtle implementation details and general immersion in VR.