Fast Accurate Point of Care COVID-19 Pandemic Diagnosis Enabled Through Advanced Lab-on-a-Chip Optical Biosensors: Opportunities and Challenges

TL;DR

This paper reviews advanced optical lab-on-a-chip biosensors for rapid, sensitive, and cost-effective COVID-19 detection, emphasizing their potential for mass production and application to various contagious viruses.

Contribution

It highlights recent developments in optical biosensors and lab-on-a-chip platforms for COVID-19 diagnosis, including integration of nanomaterials and plasmonic resonance techniques.

Findings

Optical biosensors can detect SARS-CoV-2 at ~1 fM concentration.

Lab-on-a-chip platforms enable rapid, non-invasive testing.

These technologies are adaptable for other viruses like influenza and MERS.

Abstract

The sudden rise of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic early 2020 throughout the world has called into drastic action measures to do instant detection and reduce the spread rate. The common diagnostics testing methods has been only partially effective in satisfying the booming demand for fast detection methods to contain the further spread. However, the point-of-risk accurate diagnosis of this new emerging viral infection is paramount as simultaneous normal working operation and dealing with symptoms of SARS-CoV-2 can become the norm for years to come. Sensitive cost-effective biosensor with mass production capability is crucial throughout the world until a universal vaccination become available. Optical label-free biosensors can provide a non-invasive, extremely sensitive rapid detection technique up to ~1 fM concentration along with few minutes sensing. These biosensors can be manufactured on a mass-scale (billions) to detect the COVID-19 viral load in nasal, saliva, urinal, and serological samples even if the infected person is asymptotic. Methods investigated here are the most advanced available platforms for biosensing optical devices resulted from the integration of state-of-the-art designs and materials. These approaches are including but not limited to integrated optical devices, plasmonic resonance and also emerging nanomaterial biosensors. The lab-on-a-chip platforms examined here are suitable not only for SARS-CoV-2 spike protein detection but also other contagious virions such as influenza, and middle east respiratory syndrome (MERS).