On the Transcriptomic Signature and General Stress State Associated with Aneuploidy

TL;DR

This paper discusses the common gene expression signatures and stress states associated with aneuploidy, defending previous findings against recent conflicting studies.

Contribution

It clarifies and defends prior conclusions on aneuploidy transcriptomic signatures amid recent conflicting research.

Findings

Aneuploidy is associated with a specific transcriptomic signature.

A common stress response is linked to aneuploidy.

The authors reaffirm their previous conclusions on aneuploidy gene expression.

Abstract

Whether aneuploid cells with diverse karyotypes have any properties in common has a been a subject of intense interest. A recent study by Terhorst et al. (1) reinvestigated the common aneuploidy gene expression (CAGE), disputing the conclusion of our recent work (2). In this short article, which has been submitted to PNAS as a Letter to the Editor, we explain our major concerns about Terhorst et al. and why we believe that our previous conclusion stands valid.