Designing a portable radiofrequency source for magnetic hyperthermia applications

TL;DR

This paper presents a portable RF source design for magnetic hyperthermia, enabling better testing of magnetic nanoparticles for cancer treatment by heating inside cancer cells.

Contribution

It introduces a novel portable RF source with integrated magnetization sensing for magnetic hyperthermia experiments, facilitating future biomedical nanotechnology research.

Findings

Design achieves RF frequency range suitable for hyperthermia

Enables real-time detection of nanoparticle magnetization

Supports application testing of magnetic nanoparticles in cancer therapy

Abstract

In the 21st century, new and alternative non-radioactive methods for cancer treatment have been developed. One of this is magnetic hyperthermia (MH), which is based on the ability of magnetic nanoparticles (MNP) to transduce electromagnetic energy into heat. If MNP are inside cancer cells, heat induces cells death. The success of HM as cancer therapy depends on two factors, first, the NPM properties and second, the frequency and amplitude of the radio frequency (RF) applied field. Therefore, in this work a design of a portable radio frequency source for magnetic hyperthermia experiments is presented. The design consists of two parts, the first part corresponds to the RF source composed by a RLC parallel circuit, the capacity and inductance values have been chosen in order to achieve the RF range of frequency, and the second part corresponds to the design of a magnetization sensor circuit. While the first circuit produces the RF field, the second circuit serves as a detector of the NPM induced magnetization. The development of this radiofrequency source makes it possible to determine the applicability of an NPM system in the treatment of cancer by magnetic hyperthermia, opening doors for future research focused on the application of nanotechnology in biomedicine.