Quantitative phase-contrast imaging: a bridge between qualitative phase-contrast and phase retrieval algorithms

TL;DR

This paper introduces a combined method that leverages phase contrast images to initialize phase retrieval algorithms, enabling accurate, single-shot quantitative phase imaging with reduced computational demands.

Contribution

It proposes a novel hybrid approach that integrates phase contrast imaging with phase retrieval, improving convergence and accuracy in quantitative phase measurements.

Findings

Modified phase retrieval algorithm converges reliably with phase contrast initialization.

Achieves accurate quantitative phase imaging in a single shot.

Supports both binary and continuous phase objects.

Abstract

In the last five decades, iterative phase retrieval methods draw large amount of interest across the research community as a non-interferometric approach to recover quantitative phase distributions from one (or more) intensity measurement. However, in cases where a unique solution does exist, these methods often require oversampling and high computational resources, which limits the use of this approach in important applications. On the other hand, phase contrast methods are based on a single camera exposure but provides only a qualitative description of the phase, thus are not useful for applications in which the quantitative phase description is needed. In this study we adopt a combined approach of the two above-mentioned methods to overcome their respective drawbacks. We show that a modified phase retrieval algorithm easily converges to the correct solution by initializing the algorithm with a phase-induced intensity measurement, namely with a phase contrast image of the examined object. Accurate quantitative phase measurements for both binary and continuously varying phase objects are demonstrated to support the suggested system as a single-shot quantitative phase contrast microscope.