Photo-excitation production of medically interesting isomers using high-intensity {\gamma}-ray source

TL;DR

This study explores the feasibility of producing medically useful nuclear isomers via high-intensity gamma-ray sources based on laser-electron Compton scattering, demonstrating potential for medical applications with sufficient activity levels.

Contribution

It presents a novel feasibility analysis for producing specific nuclear isomers using LCS gamma-ray beams, optimizing parameters for medical use.

Findings

Achievable isomer activity exceeds 10 mCi in 6 hours.

Optimized gamma-ray energy maximizes yield and activity.

Production method meets medical dose requirements.

Abstract

Photon-induced nuclear excitation (i.e. photo-excitation) can be used for production of nuclear isomers, which have potential applications in astrophysics, energy storing, and medical diagnosis and treatment. This paper presents a feasibility study on production of four nuclear isomers ({99m}^Tc, {103m}^Rh and {113m, 115m}^In) using high-intensity {\gamma}-ray source based on laser-electron Compton scattering (LCS), for use in the medical diagnosis and treatment. The decay properties and the medical applications of these nuclear isomers were reviewed. The cross-section curves, simulated yields and activity of product of each photo-excitation process were calculated. The cutoff energy of LCS {\gamma}-ray beam is optimized by adjusting the electron energy in order to maximize the yields as well as the activities of photo-excitation products. It is found that the achievable activity of above-mentioned isomers can exceed 10 mCi for 6-hour target irradiation at an intensity of the order of 10^{13} {\gamma}/s. Such magnitude of activity satisfies the dose requirement of medical diagnosis. Our simulation results suggest the prospect of producing medically interesting isomers with photo-excitation using the state-of-art LCS {\gamma}-ray beam facility.