Pyroptosis: Physiological roles in viral infection
Nelson Duran, Wagner J. Favaro
TL;DR
This review discusses the role of pyroptosis in viral infections, especially COVID-19, highlighting inflammasome features, infection mechanisms, and potential immunomodulatory therapies for treatment.
Contribution
It provides a comprehensive overview of pyroptosis's involvement in coronavirus infections and explores immunomodulation therapies as promising COVID-19 treatments.
Findings
Pyroptosis is linked to SARS-CoV-2 infection mechanisms.
Immunomodulation therapies show potential in COVID-19 treatment.
Protection strategies against viral infections are discussed.
Abstract
The current review focuses on important aspects of pyroptosis, such as morphological features of inflammasomes, as well as on knowledge about coronavirus infection mechanisms and the association between SARS-CoV-2 infection and cell pyroptosis. The application of immunomodulation therapies to Covid-19 patients is the most promising treatment under investigation nowadays. The possibilities of assistance to help protecting patients from infections are also addressed in the present study.
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Taxonomy
TopicsInflammasome and immune disorders · COVID-19 Clinical Research Studies · SARS-CoV-2 and COVID-19 Research