From biophysical to integrate-and-fire modelling

TL;DR

This paper introduces a methodology to derive simplified integrate-and-fire neuron models from detailed biophysical models, linking conductance modulation to firing behavior changes, demonstrated on neuromodulation examples.

Contribution

It presents a novel approach to extract low-dimensional integrate-and-fire models from complex biophysical models, enabling better understanding of neuromodulation effects.

Findings

Successfully related conductance modulation to firing mode transitions

Demonstrated method on Type I/II excitability and spiking/bursting transitions

Provided a systematic way to simplify biophysical neuron models

Abstract

This paper proposes a methodology to extract a low-dimensional integrate-and-fire model from an arbitrarily detailed single-compartment biophysical model. The method aims at relating the modulation of maximal conductance parameters in the biophysical model to the modulation of parameters in the proposed integrate-and-fire model. The approach is illustrated on two well-documented examples of cellular neuromodulation: the transition between Type I and Type II excitability and the transition between spiking and bursting.