What do we know about DNA mechanics so far?
Abhishek Aggarwal, Supriyo Naskar, Anil Kumar Sahoo, Santosh, Mogurampelly, Ashok Garai, Prabal K. Maiti
TL;DR
This paper reviews current knowledge on DNA mechanics, focusing on structural transitions, elastic properties, and the effects of environmental forces based on simulations and experiments.
Contribution
It provides a comprehensive summary of recent findings on DNA's structural and mechanical behavior under various forces and conditions.
Findings
DNA undergoes significant structural transitions under force
DNA's elastic properties vary with environmental conditions
Simulations and experiments complement each other in understanding DNA mechanics
Abstract
The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and find applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions.
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