Immunomodulatory role of black tea in the mitigation of cancer induced by inorganic arsenic

TL;DR

This paper models how black tea, as an immunomodulator, can help mitigate inorganic arsenic-induced cancer by analyzing tumor and normal cell growth dynamics, offering a potential alternative to chemotherapy.

Contribution

The study introduces a mathematical model incorporating variable immune cell influx and black tea's immunomodulatory effects to analyze cancer mitigation strategies.

Findings

Variable immune cell influx reduces tumor growth effectively.

Normal cell populations remain above healthy levels with black tea intervention.

Model provides insights into long-term tumor-normal cell dynamics.

Abstract

We present a model analysis of the tumor and normal cell growth under the influence of a carcinogenic agent, an immunomdulator (IM) and variable influx of immune cells including relevant interactions. The tumor growth is facilitated by carcinogens such as inorganic arsenic while the IM considered here is black tea (Camellia sinesnsis). The model with variable influx of immune cells is observed to have considerable advantage over the constant influx model, and while the tumor cell population is greatly mitigated, normal cell population remains above healthy levels. The evolution of normal and tumor cells are computed from the proposed model and their local stabilities are investigated analytically. Numerical simulations are performed to study the long term dynamics and an estimation of the effects of various factors is made. This helps in developing a balanced strategy for tumor mitigation without the use of chemotherapeutic drugs that usually have strong side-effects.