Not all interventions are equal for the height of the second peak

TL;DR

This study uses network simulations to analyze how different interventions affect COVID-19-like epidemic peaks, revealing that some strategies flatten the first peak but may cause larger second peaks and prolonged outbreaks.

Contribution

It demonstrates that network-based epidemic models exhibit complex behaviors, such as oscillations and second peaks, which are not captured by traditional continuous models, and evaluates intervention impacts on epidemic dynamics.

Findings

Long immunity periods can lead to epidemic extinction after the first peak.

Interventions flatten the first peak but may cause larger second peaks.

Interventions prolong the epidemic and introduce oscillations.

Abstract

In this paper we conduct a simulation study of the spread of an epidemic like COVID-19 with temporary immunity on finite spatial and non-spatial network models. In particular, we assume that an epidemic spreads stochastically on a scale-free network and that each infected individual in the network gains a temporary immunity after its infectious period is over. After the temporary immunity period is over, the individual becomes susceptible to the virus again. When the underlying contact network is embedded in Euclidean geometry, we model three different intervention strategies that aim to control the spread of the epidemic: social distancing, restrictions on travel, and restrictions on maximal number of social contacts per node. Our first finding is that on a finite network, a long enough average immunity period leads to extinction of the pandemic after the first peak, analogous to the concept of "herd immunity". For each model, there is a critical average immunity length $L_c$ above which this happens. Our second finding is that all three interventions manage to flatten the first peak (the travel restrictions most efficiently), as well as decrease the critical immunity length $L_c$, but elongate the epidemic. However, when the average immunity length $L$ is shorter than $L_c$, the price for the flattened first peak is often a high second peak: for limiting the maximal number of contacts, the second peak can be as high as 1/3 of the first peak, and twice as high as it would be without intervention. Thirdly, interventions introduce oscillations into the system and the time to reach equilibrium is, for almost all scenarios, much longer. We conclude that network-based epidemic models can show a variety of behaviors that are not captured by the continuous compartmental models.