Emerging classes of antioxidant to cancer therapy: a review of clinical and experimental studies

TL;DR

This review examines the role of antioxidants in cancer therapy, discussing their potential benefits and drawbacks based on recent clinical and experimental studies on oxidative stress and free radicals.

Contribution

It provides a comprehensive overview of recent findings on antioxidants' effects in cancer treatment, highlighting new classes and clinical trial outcomes.

Findings

Antioxidants can reduce oxidative damage but may have undesirable effects in clinical trials.

Recent studies reveal complex roles of antioxidants in cancer progression.

Natural and synthetic antioxidants show varied efficacy in clinical settings.

Abstract

This review mainly focuses on the relation between antioxidants with cancer therapy. Antioxidants have been reported to play an essential role to reduce free radical species. Free radicals commonly cause oxidative damage which is a common factor in the aging process, and also the vital factor of formation, and development of major disease specially cancer. Although, since last many decades several antioxidants belong to natural and synthetic origin have been tested in clinical trials against oxidative stress, however these clinical trials end up with undesirable effects. This review also complied with the most recent findings of oxidative stress, highlighting of free racial production, and its related oxidative damage at cellular and molecular level, with the new and existing natural and synthetic classes of free radical scavenger and their related clinical trials.