A study of resting-state EEG biomarkers for depression recognition

TL;DR

This study investigates EEG biomarkers, especially phase lagging index (PLI), for depression detection, demonstrating that intrahemispheric PLI features significantly distinguish depressed patients from controls with high accuracy.

Contribution

It identifies intrahemispheric PLI connectivity as a novel biomarker for depression recognition, outperforming other EEG features.

Findings

PLI outperforms linear and nonlinear features in classification accuracy.

Combining all features yields 82.31% accuracy in depression detection.

Intrahemispheric PLI edges are more significant than interhemispheric edges.

Abstract

Background: Depression has become a major health burden worldwide, and effective detection depression is a great public-health challenge. This Electroencephalography (EEG)-based research is to explore the effective biomarkers for depression recognition. Methods: Resting state EEG data was collected from 24 major depressive patients (MDD) and 29 normal controls using 128 channel HydroCel Geodesic Sensor Net (HCGSN). To better identify depression, we extracted different types of EEG features including linear features, nonlinear features and functional connectivity features phase lagging index (PLI) to comprehensively analyze the EEG signals in patients with MDD. And using different feature selection methods and classifiers to evaluate the optimal feature sets. Results: Functional connectivity feature PLI is superior to the linear features and nonlinear features. And when combining all the types of features to classify MDD patients, we can obtain the highest classification accuracy 82.31% using ReliefF feature selection method and logistic regression (LR) classifier. Analyzing the distribution of optimal feature set, it was found that intrahemispheric connection edges of PLI were much more than the interhemispheric connection edges, and the intrahemispheric connection edges had a significant differences between two groups. Conclusion: Functional connectivity feature PLI plays an important role in depression recognition. Especially, intrahemispheric connection edges of PLI might be an effective biomarker to identify depression. And statistic results suggested that MDD patients might exist functional dysfunction in left hemisphere.