On a bi-dimensional chemo-repulsion model with nonlinear production
Francisco Guill\'en-Gonz\'alez, Exequiel Mallea-Zepeda, \'Elder J., Villamizar-Roa

TL;DR
This paper analyzes a bi-dimensional chemo-repulsion model with nonlinear production, establishing existence, uniqueness, and optimal control solutions for different nonlinearities, with implications for biological and chemical systems modeling.
Contribution
It provides the first rigorous analysis of existence, uniqueness, and optimal control for a nonlinear chemo-repulsion PDE with bilinear control in 2D domains.
Findings
Proved global strong solutions for quadratic production ($p=2$).
Derived optimality system and regularity of Lagrange multipliers.
Extended analysis to sub-quadratic production ($1<p<2$).
Abstract
In this paper, we study the following parabolic chemo-repulsion with nonlinear production model: This problem is related to a bilinear control problem, where the state is the cell density and the chemical concentration respectively, and the control acts in a bilinear form in the chemical equation. For domains, we first consider the case of quadratic signal production (), proving the existence and uniqueness of global strong state solution for each control, and the existence of global optimum solution. Afterwards, we deduce the optimality system for any local optimum via a Lagrange multiplier Theorem, proving regularity of the Lagrange multipliers. Finally, we consider the case of signal production with .
Peer Reviews
No public reviews on file for this paper yet. If you reviewed it on a platform where reviews are public (OpenReview, ICLR, NeurIPS, ICML), you can paste yours below so the community can read it here.
Videos
No videos yet. Explain this paper in a talk, walkthrough, or lecture? Add one.
Taxonomy
TopicsMathematical Biology Tumor Growth · Gene Regulatory Network Analysis · Mathematical and Theoretical Epidemiology and Ecology Models
