Chromatin Structure Changes in Human Disease: A Mini Review

TL;DR

This mini review summarizes recent research on how changes in chromatin structure are linked to various human diseases, highlighting a shift towards understanding nuclear regulation in disease development.

Contribution

It compiles and analyzes recent studies from 2018-2019 on chromatin alterations in diseases, emphasizing the focus on cancer, Alzheimer's, and hereditary conditions.

Findings

Chromatin transformations are associated with cancer, Alzheimer's, and hereditary diseases.

Research is increasingly focused on nuclear regulation of disease origin.

There is a trend towards studying chromatin's role in noncommunicable diseases.

Abstract

There are many experimental data indicating the correlations of the changes in high level of organization of chromatin in human cells and changes in the state of the whole organism related to disease, state of tiredness or aging. In our previous work: arXiv.org-2018 (1812.00186) we analyzed the publications on the topic up to 2017. In this work we focused on works upon the problem of connection of the state of chromatin with human diseases published in 2018-2019. In the modern literature the most attention is paid to problem of chromatin transformations in different forms of cancer, Alzheimer'r disease, and hereditary diseases. Summing up, the tendency of scientific research of noncommunicable diseases is shifting towards investigation of aspects of nuclear regulation of disease origin, connected with conformation of chromatin.