Treatment of carcinomas using atmospheric pressure plasma jets: from targets to in vivo models to investigate innocuity and therapeutic efficiency

TL;DR

This study explores atmospheric pressure plasma jets (APPJ) as a safe and effective cancer treatment, calibrating them on models and testing in mice to assess safety and therapeutic potential.

Contribution

It introduces a two-step methodology for calibrating APPJ on biological mimics and evaluating their safety and efficacy in live animal models.

Findings

APPJ can be calibrated on biological targets mimicking living tissues.

APPJ demonstrates safety and therapeutic effects in murine cancer models.

The approach shows promise for non-invasive cancer treatment.

Abstract

Atmospheric pressure plasma jets (APPJ) are investigated as an efficient approach to induce antitumor effects of cancerous tissues without inducing any damage (e.g. dessication, burnings). For this, a two-steps methodology has been developed where first APPJ are calibrated and characterized on targets mimicking electrical properties of living organisms (mice, human body) and second where they are applied on murine models to demonstrate their innocuity and therapeutic efficiency.