Possible traces of resonance signaling in the genome

TL;DR

This study investigates the presence of resonance signaling in genomes by identifying enriched repeat sequences, called HIDERs, which may facilitate sequence-specific resonance communication in biological systems.

Contribution

It introduces the concept of HIDERs, enriched in genomes, as potential mediators of resonance signaling, supported by genomic analysis across multiple species.

Findings

Enrichment of purine-pyrimidine HIDERs in mammalian, insect, and plant genomes.

Detection of hydrogen-bond-based HIDERs with similar enrichment patterns.

First evidence supporting sequence-specific resonance signaling in genomes.

Abstract

Although theories regarding the role of sequence-specific DNA resonance in biology have abounded for over 40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonance signaling, the number of oscillating DNA sequences per genome should be exceptionally high and that, therefore, genomic repeats of various sizes are good candidates for serving as resonators. Moreover, it was suggested that for the two DNA sequences to resonate, they do not necessarily have to be identical. Therefore, the existence of sequences differing in the primary sequence but having similar resonating sub-structures was proposed. It was hypothesized that such sequences, named HIDERs, would be enriched in the genomes of multicellular species. Specifically, it was hypothesized that delocalized electron clouds of purine-pyrimidine sequences could serve as the basis of HIDERs. The consequent genomic analysis confirmed the enrichment of purine-pyrimidine HIDERs in a few selected genomes of mammals, an insect, and a plant, compared to randomized sequence controls. Similarly, it was suggested that hypothetical delocalized proton clouds of the hydrogen bonds of multiple stacked bases could serve as sequence-dependent hydrogen-bond-based HIDERs. Similarly, the enrichment of such HIDERs was observed. It is suggested that these enrichments are the first evidence in support of sequence-specific resonance signaling in the genome.