MGP-AttTCN: An Interpretable Machine Learning Model for the Prediction of Sepsis

TL;DR

This paper introduces MGP-AttTCN, an interpretable deep learning model combining Gaussian Processes and attention mechanisms, to predict sepsis early using EHR data, outperforming existing models.

Contribution

The work presents a novel joint multitask Gaussian Process and attention-based model for early sepsis prediction with improved accuracy and interpretability.

Findings

MGP-AttTCN achieves higher AUROC and AUPR than previous models.

Different labeling heuristics affect task difficulty and model performance.

The model demonstrates effective early prediction of sepsis five hours prior to onset.

Abstract

With a mortality rate of 5.4 million lives worldwide every year and a healthcare cost of more than 16 billion dollars in the USA alone, sepsis is one of the leading causes of hospital mortality and an increasing concern in the ageing western world. Recently, medical and technological advances have helped re-define the illness criteria of this disease, which is otherwise poorly understood by the medical society. Together with the rise of widely accessible Electronic Health Records, the advances in data mining and complex nonlinear algorithms are a promising avenue for the early detection of sepsis. This work contributes to the research effort in the field of automated sepsis detection with an open-access labelling of the medical MIMIC-III data set. Moreover, we propose MGP-AttTCN: a joint multitask Gaussian Process and attention-based deep learning model to early predict the occurrence of sepsis in an interpretable manner. We show that our model outperforms the current state-of-the-art and present evidence that different labelling heuristics lead to discrepancies in task difficulty. For instance, when predicting sepsis five hours prior to onset on our new realistic labels, our proposed model achieves an area under the ROC curve of 0.660 and an area under the PR curve of 0.483, whereas the (less interpretable) previous state-of-the-art model (MGP-TCN) achieves 0.635 AUROC and 0.460 AUPR and the popular commercial InSight model achieves 0.490 AUROC and 0.359 AUPR.