Expert2Coder: Capturing Divergent Brain Regions Using Mixture of Regression Experts

TL;DR

This paper introduces Expert2Coder, a mixture of regression experts model that captures functionally specialized brain regions in fMRI data, improving prediction accuracy over traditional single-model approaches.

Contribution

It proposes a novel mixture of experts framework to model brain region specialization and integration, aligning with neuroscience theories.

Findings

MoRE outperforms conventional models in prediction accuracy

Clusters brain regions based on similar activation patterns

Supports modularity and specialization in brain function

Abstract

fMRI semantic category understanding using linguistic encoding models attempts to learn a forward mapping that relates stimuli to the corresponding brain activation. State-of-the-art encoding models use a single global model (linear or non-linear) to predict brain activation given the stimulus. However, the critical assumption in these methods is that a priori different brain regions respond the same way to all the stimuli, that is, there is no modularity or specialization assumed for any region. This goes against the modularity theory, supported by many cognitive neuroscience investigations suggesting that there are functionally specialized regions in the brain. In this paper, we achieve this by clustering similar regions together and for every cluster we learn a different linear regression model using a mixture of linear experts model. The key idea here is that each linear expert captures the behaviour of similar brain regions. Given a new stimulus, the utility of the proposed model is twofold (i) predicts the brain activation as a weighted linear combination of the activations of multiple linear experts and (ii) to learn multiple experts corresponding to different brain regions. We argue that each expert captures activity patterns related to a particular region of interest (ROI) in the human brain. This study helps in understanding the brain regions that are activated together given different kinds of stimuli. Importantly, we suggest that the mixture of regression experts (MoRE) framework successfully combines the two principles of organization of function in the brain, namely that of specialization and integration. Experiments on fMRI data from paradigm 1 [1]where participants view linguistic stimuli show that the proposed MoRE model has better prediction accuracy compared to that of conventional models.