The recent advances in the mathematical modelling of human pluripotent stem cells

TL;DR

This paper reviews recent mathematical models of human pluripotent stem cells, focusing on cell movement, growth, colony formation, and differentiation to enhance understanding and experimental optimization.

Contribution

It provides a comprehensive overview of the latest mathematical approaches applied to hPSC behaviors, highlighting advances in modeling key cellular processes.

Findings

Enhanced understanding of cell kinematics and proliferation.

Development of non-invasive prognostic tools.

Improved models for pluripotency and differentiation.

Abstract

Human pluripotent stem cells hold great promise for developments in regenerative medicine and drug design. The mathematical modelling of stem cells and their properties is necessary to understand and quantify key behaviours and develop non-invasive prognostic modelling tools to assist in the optimisation of laboratory experiments. Here, the recent advances in the mathematical modelling of hPSCs are discussed, including cell kinematics, cell proliferation and colony formation, and pluripotency and differentiation.