Tumour Induced Angiogenesis and Its Simulation

TL;DR

This paper reviews tumour-induced angiogenesis and introduces a cellular automata model to simulate the complex process, highlighting its role in tumour growth and metastasis.

Contribution

It presents a novel MATLAB-based cellular automata model to simulate tumour angiogenesis, enhancing understanding of its dynamics and effects.

Findings

Model successfully simulates angiogenesis process

Highlights role of angiogenesis in tumour spread

Provides a tool for further research and analysis

Abstract

Due to over-metabolism, the tumour cells become hypoxic. To overcome this situation tumour cells secret several chemical substrates to attract nearby blood vessels towards it (angiogenesis). Transition from avascular to vascular tumour is possible with the initiation of angiogenesis. Angiogenesis also plays a crucial role to spread the cancer cells and its colonization at the distant locations of the body (metastasis). In this paper, we briefly review the processes and factors which directly affect tumour angiogenesis or may get affected by it. A model based on cellular automata is developed to demonstrate this complex process through MATLAB based simulation.