Brain Energetics, Mitochondria, and Traumatic Brain Injury

TL;DR

This paper reviews the relationship between brain energetics, mitochondria, and traumatic brain injury, proposing a framework for understanding mechanisms based on energy metabolism and optimal energetic decisions.

Contribution

It introduces a new framework connecting brain energetics and mitochondria to traumatic brain injury mechanisms, integrating current knowledge in these fields.

Findings

Mitochondrial dysfunction is linked to traumatic brain injury.

Optimal energetic decisions influence injury outcomes.

A proposed framework unifies brain energetics with injury mechanisms.

Abstract

We review current thinking about, and draw connections between, brain energetics and metabolism, mitochondria and traumatic brain injury. In addition to summarizing current thinking in these disciplines, our goal is to suggest a framework for mechanisms and pathways based on optimal energetic decisions.